Thick black smoke is clouding the area and the residents are being advised to keep their windows and doors closed.
Ten fire engines and 72 fire fighters from Soho, Islington, Holloway, Shoreditch, Homerton, Bethnal Green, Whitechapel, Tottenham and Poplar fire stations are at the scene.
A man has been taken to hospital suffering from smoke inhalation and burns, the London Fire Brigade tweeted. Emergency crews were called at 1pm and the cause of the blaze is currently unknown.
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