Hundreds of people have been killed after a magnitude 7.9 earthquake struck Nepal causing extensive damage in the capital Kathmandu.
At least 876 have been confirmed dead across the country following the strongest quake to hit Nepal in 80 years, according to police.
The quake toppled Kathmandu's iconic nine-storey Dharahara tower, with rescuers left scrambling to reach some 50 people reported to have been trapped under the rubble.
Earlier police removed around a dozen bodies from the 19th Century UNESCO-recognised monument, also known as the Bhimsen Tower.
Tremors were also felt in neighbouring India, with 34 people, including a 15-year-old girl, reported to have been killed in the north of the country.
The quake also triggered a "huge avalanche" on Mount Everest, leaving at least ten climbers dead.
Mountaineer Alex Gavan tweeted from Mount Pumori: "Everest base camp huge earthquake then huge avalanche from pumori.
"Running for life from my tent. Unhurt. Many many people up the mountain."
Another climber, Daniel Mazur, said Everest base camp had been "severely damaged" and his team was trapped.
"Please pray for everyone," he tweeted.
The quake struck 80km (50 miles) east of the central city of Pokhara shortly before noon local time and was followed by a magnitude 6.6 aftershock, with tremors felt for hours afterwards. It was relatively shallow, making it more powerful.
Little is yet known about the extent of damage to Pokhara, but in the densely-populated city of Kathmandu hospitals are struggling to cope.
Televised images from outside the city's main hospital show the injured being forced to wait outside on the street for treatment.
A number of centuries-old temples have been destroyed and there are unconfirmed reports that the densely-populated city's main airport has closed, according to Sky News' India producer Neville Lazarus.
Nepal's Information Minister Minendra Rijal has told India's NDTV station that rescue teams are at the scene.
"It was a pretty massive earthquake here, the strongest I've ever felt in my life," photojournalist Nayantara, who is in Pokhara, told Sky News.
"There is quite a lot of damage. The building I was in has quite a lot of cracks in it," she said.
Another witness tweeted: "LOTS of shaking. Hid under table, then ran outside. Still feel like swaying. Cables/walls down."
"Lots of panic, people wandering in the streets," @jonk said, adding that people were gathering in the middle of an intersection to avoid falling debris.
Tremors could also be felt as far away as Pakistan, Bangladesh and Tibet.
India's Prime Minister Narendra Modi tweeted: "We are in the process of finding more information and are working to reach out to those affected, both at home & in Nepal."
Prime Minister David Cameron tweeted: "Shocking news about the earthquake in Nepal - the UK will do all we can to help those caught up in it."
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